Daniel Judge

In the Gallagher Lab, we use yeast as a model organism to study the genetics and molecular biology of cellular stress response. My studies focus on ribosome damage resulting from ribosome-inactivating proteins (RIPs), a category of potent toxins including ricin and sarcin. Using a RIP expression vector, we can observe changes to the transcriptome and proteome and track yeast growth suppression. Additionally, genetic screens can identify key pathways necessary for RIP-induced growth suppression. This research aims to explore disruptions to cellular homeostasis and improve our understanding of how cells respond to stress.